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Disclosure - Long-Term Debt - Schedule of Future Minimum Payments under Loan Agreement (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Liabilities Related to Sale of Future Royalties - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Liabilities Related to Sale of Future Royalties - Schedule Represents Allocation of Transaction Consideration on a Relative Fair Value Basis to the Liability and the Common Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Liabilities Related to Sale of Future Royalties - Schedule Represents Activity Within Liabilities Related to Sale of Future Royalties (Detail) link:calculationLink link:presentationLink link:definitionLink 151 - Disclosure - Stockholders' Equity - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 152 - Disclosure - Stockholders' Equity - Outstanding Warrants (Detail) link:calculationLink link:presentationLink link:definitionLink 153 - 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Disclosure - Long-Term Debt - Schedule of Future Minimum Payments under Loan Agreement (Detail) (Alternate 1) link:calculationLink link:presentationLink link:definitionLink